2025
Lorenzon, Altea; Jiang, Xiao; Gang, Grace; Stayman, J. Webster
Joint Reconstruction and Scatter Estimation in Cone-beam CT using Diffusion Posterior Sampling Conference Forthcoming
SPIE Medical Imaging, Forthcoming.
BibTeX | Tags: Artifact Correction, CBCT, Machine Learning/Deep Learning, Scatter Estimation
@conference{Lorenzon2025,
title = {Joint Reconstruction and Scatter Estimation in Cone-beam CT using Diffusion Posterior Sampling},
author = {Altea Lorenzon and Xiao Jiang and Grace Gang and J. Webster Stayman},
year = {2025},
date = {2025-02-19},
urldate = {2025-02-19},
booktitle = {SPIE Medical Imaging},
keywords = {Artifact Correction, CBCT, Machine Learning/Deep Learning, Scatter Estimation},
pubstate = {forthcoming},
tppubtype = {conference}
}
2021
Li, Junyuan; Gang, Grace; Stayman, J. Webster
Mitigating unknown biases in CT data using machine learning Proceedings Article
In: SPIE Medical Imaging, pp. 1159541, International Society for Optics and Photonics, 2021.
Links | BibTeX | Tags: Artifact Correction, Machine Learning/Deep Learning
@inproceedings{Li2021,
title = {Mitigating unknown biases in CT data using machine learning},
author = {Junyuan Li and Grace Gang and J. Webster Stayman},
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11595/1159541/Mitigating-unknown-biases-in-CT-data-using-machine-learning/10.1117/12.2582274.full},
doi = {10.1117/12.2582274},
year = {2021},
date = {2021-02-15},
booktitle = {SPIE Medical Imaging},
volume = {11595},
pages = {1159541},
publisher = {International Society for Optics and Photonics},
keywords = {Artifact Correction, Machine Learning/Deep Learning},
pubstate = {published},
tppubtype = {inproceedings}
}
2020
Liu, Stephen; Cao, Qian; Tivnan, Matt; Tilley, Steven; Siewerdsen, Jeffrey H.; Stayman, J. Webster; Zbijewski, Wojciech
Model-based dual-energy tomographic image reconstruction of objects containing known metal components Journal Article
In: Physics in Medicine and Biology, vol. 65, no. 24, pp. 245046, 2020.
Links | BibTeX | Tags: Artifact Correction, Known Components, MBIR, Metal Artifacts, Spectral X-ray/CT
@article{Liu2020bb,
title = {Model-based dual-energy tomographic image reconstruction of objects containing known metal components},
author = {Stephen Liu and Qian Cao and Matt Tivnan and Steven Tilley and Jeffrey H. Siewerdsen and J. Webster Stayman and Wojciech Zbijewski},
url = {https://pubmed.ncbi.nlm.nih.gov/33113519/},
doi = {10.1088/1361-6560/abc5a9},
year = {2020},
date = {2020-12-15},
journal = {Physics in Medicine and Biology},
volume = {65},
number = {24},
pages = {245046},
keywords = {Artifact Correction, Known Components, MBIR, Metal Artifacts, Spectral X-ray/CT},
pubstate = {published},
tppubtype = {article}
}
2019
Cao, Qian; Sisniega, Alejandro; Stayman, J. Webster; Yorkston, John; Siewerdsen, Jeffrey H.; Zbijewski, Wojciech
Quantitative cone-beam CT of bone mineral density using model-based reconstruction Proceedings Article
In: Proc. SPIE Medical Imaging, pp. 109480Y-1-6, 2019.
Links | BibTeX | Tags: Artifact Correction, Beam Hardening, CBCT, Extremities, MBIR
@inproceedings{Cao2019,
title = {Quantitative cone-beam CT of bone mineral density using model-based reconstruction},
author = {Qian Cao and Alejandro Sisniega and J. Webster Stayman and John Yorkston and Jeffrey H. Siewerdsen and Wojciech Zbijewski },
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10948/109480Y/Quantitative-cone-beam-CT-of-bone-mineral-density-using-model/10.1117/12.2513216.full},
doi = {10.1117/12.2513216},
year = {2019},
date = {2019-03-01},
booktitle = {Proc. SPIE Medical Imaging},
volume = {10948},
pages = {109480Y-1-6},
keywords = {Artifact Correction, Beam Hardening, CBCT, Extremities, MBIR},
pubstate = {published},
tppubtype = {inproceedings}
}
2018
Sisniega, Alejandro; Zbijewski, Wojciech; Wu, Pengwei; Stayman, J. Webster; Aygun, Nafi; Stevens, R.; Wang, Xiaohui; Foos, David H.; Siewerdsen, Jeffrey H.
Multi-Motion Compensation for High-Quality Cone-Beam CT of the Head Proceedings Article
In: International Conference on Image Formation in X-Ray Computed Tomography, pp. 73-77, 2018.
BibTeX | Tags: Artifact Correction, Head/Neck, Motion Compensation
@inproceedings{Sisniega2018b,
title = {Multi-Motion Compensation for High-Quality Cone-Beam CT of the Head},
author = {Alejandro Sisniega and Wojciech Zbijewski and Pengwei Wu and J. Webster Stayman and Nafi Aygun and R. Stevens and Xiaohui Wang and David H. Foos and Jeffrey H. Siewerdsen },
year = {2018},
date = {2018-05-20},
booktitle = {International Conference on Image Formation in X-Ray Computed Tomography},
pages = {73-77},
keywords = {Artifact Correction, Head/Neck, Motion Compensation},
pubstate = {published},
tppubtype = {inproceedings}
}
Uneri, Ali; Yi, T.; Zhang, Xiaoxuan; Stayman, J. Webster; Helm, Patrick; Osgood, Greg M.; Theodore, Nick; Siewerdsen, Jeffrey H.
3D-2D known-component registration for metal artifact reduction in cone-beam CT Proceedings Article
In: International Conference on Image Formation in X-Ray Computed Tomography, pp. 151-155, 2018.
Links | BibTeX | Tags: Artifact Correction, Image Registration, Known Components, Metal Artifacts, Spine
@inproceedings{Uneri2018b,
title = {3D-2D known-component registration for metal artifact reduction in cone-beam CT},
author = {Ali Uneri and T. Yi and Xiaoxuan Zhang and J. Webster Stayman and Patrick Helm and Greg M. Osgood and Nick Theodore and Jeffrey H. Siewerdsen },
url = {https://aiai.jhu.edu/papers/CT2018_uneri.pdf},
year = {2018},
date = {2018-05-20},
booktitle = {International Conference on Image Formation in X-Ray Computed Tomography},
pages = {151-155},
keywords = {Artifact Correction, Image Registration, Known Components, Metal Artifacts, Spine},
pubstate = {published},
tppubtype = {inproceedings}
}
Tilley, Steven; Sisniega, Alejandro; Siewerdsen, Jeffrey H.; Stayman, J. Webster
High-Fidelity Modeling of Detector Lag and Gantry Motion in CT Reconstruction Proceedings Article
In: International Conference on Image Formation in X-Ray Computed Tomography, pp. 318-322, 2018.
Links | BibTeX | Tags: Artifact Correction, High-Fidelity Modeling, High-Resolution CT
@inproceedings{Tilley2018b,
title = {High-Fidelity Modeling of Detector Lag and Gantry Motion in CT Reconstruction},
author = {Steven Tilley and Alejandro Sisniega and Jeffrey H. Siewerdsen and J. Webster Stayman },
url = {https://aiai.jhu.edu/papers/CT2018_tilley.pdf},
year = {2018},
date = {2018-05-20},
booktitle = {International Conference on Image Formation in X-Ray Computed Tomography},
pages = {318-322},
keywords = {Artifact Correction, High-Fidelity Modeling, High-Resolution CT},
pubstate = {published},
tppubtype = {inproceedings}
}
Sisniega, Alejandro; Zbijewski, Wojciech; Wu, Pengwei; Stayman, J. Webster; Koliatsos, Vassilis; Aygun, Nafi; Stevens, R.; Wang, Xiaohui; Foos, David H.; Siewerdsen, Jeffrey H.
Image quality, scatter, dose in compact CBCT systems with flat and curved detectors Journal Article
In: Proc. SPIE Medical Imaging, vol. 10573, pp. 1015734E-1-7, 2018.
Links | BibTeX | Tags: Artifact Correction, Head/Neck, Scatter Estimation, System Assessment, System Design
@article{Sisniega2018,
title = {Image quality, scatter, dose in compact CBCT systems with flat and curved detectors},
author = {Alejandro Sisniega and Wojciech Zbijewski and Pengwei Wu and J. Webster Stayman and Vassilis Koliatsos and Nafi Aygun and R. Stevens and Xiaohui Wang and David H. Foos and Jeffrey H. Siewerdsen },
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10573/2293872/Image-quality-scatter-and-dose-in-compact-CBCT-systems-with/10.1117/12.2293872.full},
doi = {10.1117/12.2293872},
year = {2018},
date = {2018-02-15},
journal = {Proc. SPIE Medical Imaging},
volume = {10573},
pages = {1015734E-1-7},
keywords = {Artifact Correction, Head/Neck, Scatter Estimation, System Assessment, System Design},
pubstate = {published},
tppubtype = {article}
}
2017
Xu, Shiyu; Khanna, A. Jay; Siewerdsen, Jeffrey H.; Stayman, J. Webster
Polyenergetic known-component CT reconstruction with unknown material compositions and unknown x-ray spectra Journal Article
In: Physics in medicine and biology, vol. 62, no. 8, pp. 3352-3374, 2017.
Links | BibTeX | Tags: Artifact Correction, Beam Hardening, Known Components, MBIR, Metal Artifacts
@article{Xu2017,
title = {Polyenergetic known-component CT reconstruction with unknown material compositions and unknown x-ray spectra},
author = {Shiyu Xu and A. Jay Khanna and Jeffrey H. Siewerdsen and J. Webster Stayman },
url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728157/
http://iopscience.iop.org/article/10.1088/1361-6560/aa6285/meta
},
doi = {10.1088/1361-6560/aa6285},
year = {2017},
date = {2017-03-28},
journal = {Physics in medicine and biology},
volume = {62},
number = {8},
pages = {3352-3374},
keywords = {Artifact Correction, Beam Hardening, Known Components, MBIR, Metal Artifacts},
pubstate = {published},
tppubtype = {article}
}
Sisniega, Alejandro; Xu, Jennifer; Dang, Hao; Zbijewski, Wojciech; Stayman, J. Webster; Mow, Michael; Koliatsos, Vassilis; Aygun, Nafi; Wang, Xiaohui; Foos, David H.; Siewerdsen, Jeffrey H.
Development and clinical translation of a cone-beam CT scanner for high-quality imaging of intracranial hemorrhage Proceedings Article
In: Flohr, Thomas G.; Lo, Joseph Y.; Schmidt, Taly Gilat (Ed.): SPIE Medical Imaging, pp. 101320K, 2017.
Links | BibTeX | Tags: Artifact Correction, Head/Neck, System Assessment, System Design
@inproceedings{Sisniega2017a,
title = {Development and clinical translation of a cone-beam CT scanner for high-quality imaging of intracranial hemorrhage},
author = {Alejandro Sisniega and Jennifer Xu and Hao Dang and Wojciech Zbijewski and J. Webster Stayman and Michael Mow and Vassilis Koliatsos and Nafi Aygun and Xiaohui Wang and David H. Foos and Jeffrey H. Siewerdsen},
editor = {Thomas G. Flohr and Joseph Y. Lo and Taly Gilat Schmidt},
url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2255670},
doi = {10.1117/12.2255670},
year = {2017},
date = {2017-03-01},
booktitle = {SPIE Medical Imaging},
volume = {10132},
pages = {101320K},
keywords = {Artifact Correction, Head/Neck, System Assessment, System Design},
pubstate = {published},
tppubtype = {inproceedings}
}
Xu, Shiyu; Khanna, A. Jay; Siewerdsen, Jeffrey H.; Stayman, J. Webster
Polyenergetic known-component CT reconstruction with unknown material compositions and unknown x-ray spectra Journal Article
In: Physics in Medicine and Biology, vol. 62, no. 8, pp. 3352-3374, 2017.
Links | BibTeX | Tags: Artifact Correction, Beam Hardening, Known Components, Metal Artifacts
@article{Xu2017,
title = {Polyenergetic known-component CT reconstruction with unknown material compositions and unknown x-ray spectra},
author = {Shiyu Xu and A. Jay Khanna and Jeffrey H. Siewerdsen and J. Webster Stayman},
url = {https://www.ncbi.nlm.nih.gov/pubmed/28230539
http://iopscience.iop.org/article/10.1088/1361-6560/aa6285/meta},
doi = {10.1088/1361-6560/aa6285},
year = {2017},
date = {2017-02-23},
journal = {Physics in Medicine and Biology},
volume = {62},
number = {8},
pages = {3352-3374},
keywords = {Artifact Correction, Beam Hardening, Known Components, Metal Artifacts},
pubstate = {published},
tppubtype = {article}
}
Dang, Hao; Stayman, J. Webster; Sisniega, Alejandro; Zbijewski, Wojciech; Xu, Jennifer; Wang, Xiaohui; Foos, David H.; Aygun, Nafi; Koliatsos, Vassilis; Siewerdsen, Jeffrey H.
Multi-resolution statistical image reconstruction for mitigation of truncation effects: application to cone-beam CT of the head Journal Article
In: Physics in Medicine and Biology, vol. 62, no. 2, pp. 539-559, 2017, ISSN: 0031-9155.
Links | BibTeX | Tags: Artifact Correction, Fast Algorithms, Head/Neck
@article{Dang2017,
title = {Multi-resolution statistical image reconstruction for mitigation of truncation effects: application to cone-beam CT of the head},
author = {Hao Dang and J. Webster Stayman and Alejandro Sisniega and Wojciech Zbijewski and Jennifer Xu and Xiaohui Wang and David H. Foos and Nafi Aygun and Vassilis Koliatsos and Jeffrey H. Siewerdsen},
url = {http://stacks.iop.org/0031-9155/62/i=2/a=539?key=crossref.8d03553e9159a88e56933c7faab62387},
doi = {10.1088/1361-6560/aa52b8},
issn = {0031-9155},
year = {2017},
date = {2017-01-01},
journal = {Physics in Medicine and Biology},
volume = {62},
number = {2},
pages = {539-559},
keywords = {Artifact Correction, Fast Algorithms, Head/Neck},
pubstate = {published},
tppubtype = {article}
}
2016
Cao, Qian; Zbijewski, Wojciech; Sisniega, Alejandro; Yorkston, John; Siewerdsen, Jeffrey H.; Stayman, J. Webster
Multiresolution iterative reconstruction in high-resolution extremity cone-beam CT Journal Article
In: Physics in Medicine and Biology, vol. 61, no. 20, pp. 7263-7281, 2016, ISSN: 0031-9155.
Links | BibTeX | Tags: Artifact Correction, Extremities, Fast Algorithms, High-Resolution CT
@article{Cao2016,
title = {Multiresolution iterative reconstruction in high-resolution extremity cone-beam CT},
author = {Qian Cao and Wojciech Zbijewski and Alejandro Sisniega and John Yorkston and Jeffrey H. Siewerdsen and J. Webster Stayman},
url = {http://stacks.iop.org/0031-9155/61/i=20/a=7263?key=crossref.3714aec7223f83ec2e527f7be1ae5e4f},
doi = {10.1088/0031-9155/61/20/7263},
issn = {0031-9155},
year = {2016},
date = {2016-10-03},
journal = {Physics in Medicine and Biology},
volume = {61},
number = {20},
pages = {7263-7281},
keywords = {Artifact Correction, Extremities, Fast Algorithms, High-Resolution CT},
pubstate = {published},
tppubtype = {article}
}
Sisniega, Alejandro; Stayman, J. Webster; Cao, Qian; Yorkston, John; Siewerdsen, Jeffrey H.; Zbijewski, Wojciech
Motion Estimation Using a Penalized Image Sharpness Criterion for Resolution Recovery in Extremities Cone-Beam CT Proceedings Article
In: 4th International Conference on Image Formation in X-Ray Computed Tomography, pp. 549–552, 2016.
Links | BibTeX | Tags: Artifact Correction, CBCT, Extremities, High-Resolution CT, Motion Compensation
@inproceedings{Sisniega2016a,
title = {Motion Estimation Using a Penalized Image Sharpness Criterion for Resolution Recovery in Extremities Cone-Beam CT},
author = {Alejandro Sisniega and J. Webster Stayman and Qian Cao and John Yorkston and Jeffrey H. Siewerdsen and Wojciech Zbijewski },
url = {https://aiai.jhu.edu/papers/CT2016_Sisniega.pdf},
year = {2016},
date = {2016-01-01},
booktitle = {4th International Conference on Image Formation in X-Ray Computed Tomography},
pages = {549--552},
keywords = {Artifact Correction, CBCT, Extremities, High-Resolution CT, Motion Compensation},
pubstate = {published},
tppubtype = {inproceedings}
}
2015
Dang, Hao; Stayman, J. Webster; Sisniega, Alejandro; Xu, Jennifer; Zbijewski, Wojciech; Wang, Xiaohui; Foos, David H.; Aygun, Nafi; Koliatsos, Vassilis; Siewerdsen, Jeffrey H.
Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: application to high-quality head imaging. Journal Article
In: Physics in medicine and biology, vol. 60, no. 16, pp. 6153–75, 2015, ISSN: 1361-6560.
Abstract | Links | BibTeX | Tags: Artifact Correction, CBCT, Head/Neck, High-Fidelity Modeling, MBIR
@article{dang2015statistical,
title = {Statistical reconstruction for cone-beam CT with a post-artifact-correction noise model: application to high-quality head imaging.},
author = {Hao Dang and J. Webster Stayman and Alejandro Sisniega and Jennifer Xu and Wojciech Zbijewski and Xiaohui Wang and David H. Foos and Nafi Aygun and Vassilis Koliatsos and Jeffrey H. Siewerdsen },
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4545529},
doi = {10.1088/0031-9155/60/16/6153},
issn = {1361-6560},
year = {2015},
date = {2015-08-01},
journal = {Physics in medicine and biology},
volume = {60},
number = {16},
pages = {6153--75},
publisher = {IOP Publishing},
abstract = {Non-contrast CT reliably detects fresh blood in the brain and is the current front-line imaging modality for intracranial hemorrhage such as that occurring in acute traumatic brain injury (contrast ~40-80 HU, size textgreater 1 mm). We are developing flat-panel detector (FPD) cone-beam CT (CBCT) to facilitate such diagnosis in a low-cost, mobile platform suitable for point-of-care deployment. Such a system may offer benefits in the ICU, urgent care/concussion clinic, ambulance, and sports and military theatres. However, current FPD-CBCT systems face significant challenges that confound low-contrast, soft-tissue imaging. Artifact correction can overcome major sources of bias in FPD-CBCT but imparts noise amplification in filtered backprojection (FBP). Model-based reconstruction improves soft-tissue image quality compared to FBP by leveraging a high-fidelity forward model and image regularization. In this work, we develop a novel penalized weighted least-squares (PWLS) image reconstruction method with a noise model that includes accurate modeling of the noise characteristics associated with the two dominant artifact corrections (scatter and beam-hardening) in CBCT and utilizes modified weights to compensate for noise amplification imparted by each correction. Experiments included real data acquired on a FPD-CBCT test-bench and an anthropomorphic head phantom emulating intra-parenchymal hemorrhage. The proposed PWLS method demonstrated superior noise-resolution tradeoffs in comparison to FBP and PWLS with conventional weights (viz. at matched 0.50 mm spatial resolution},
keywords = {Artifact Correction, CBCT, Head/Neck, High-Fidelity Modeling, MBIR},
pubstate = {published},
tppubtype = {article}
}
Sisniega, Alejandro; Zbijewski, Wojciech; Xu, Jennifer; Dang, Hao; Stayman, J. Webster; Yorkston, John; Aygun, Nafi; Koliatsos, Vassilis; Siewerdsen, Jeffrey H.
High-fidelity artifact correction for cone-beam CT imaging of the brain. Journal Article
In: Physics in medicine and biology, vol. 60, no. 4, pp. 1415–39, 2015, ISSN: 1361-6560.
Abstract | Links | BibTeX | Tags: Artifact Correction, Beam Hardening, CBCT, Head/Neck, Scatter Estimation
@article{Sisniega2015,
title = {High-fidelity artifact correction for cone-beam CT imaging of the brain.},
author = {Alejandro Sisniega and Wojciech Zbijewski and Jennifer Xu and Hao Dang and J. Webster Stayman and John Yorkston and Nafi Aygun and Vassilis Koliatsos and Jeffrey H. Siewerdsen },
url = {http://www.ncbi.nlm.nih.gov/pubmed/25611041},
doi = {10.1088/0031-9155/60/4/1415},
issn = {1361-6560},
year = {2015},
date = {2015-02-01},
journal = {Physics in medicine and biology},
volume = {60},
number = {4},
pages = {1415--39},
abstract = {CT is the frontline imaging modality for diagnosis of acute traumatic brain injury (TBI), involving the detection of fresh blood in the brain (contrast of 30-50 HU, detail size down to 1 mm) in a non-contrast-enhanced exam. A dedicated point-of-care imaging system based on cone-beam CT (CBCT) could benefit early detection of TBI and improve direction to appropriate therapy. However, flat-panel detector (FPD) CBCT is challenged by artifacts that degrade contrast resolution and limit application in soft-tissue imaging. We present and evaluate a fairly comprehensive framework for artifact correction to enable soft-tissue brain imaging with FPD CBCT. The framework includes a fast Monte Carlo (MC)-based scatter estimation method complemented by corrections for detector lag, veiling glare, and beam hardening.The fast MC scatter estimation combines GPU acceleration, variance reduction, and simulation with a low number of photon histories and reduced number of projection angles (sparse MC) augmented by kernel de-noising to yield a runtime of ~4 min per scan. Scatter correction is combined with two-pass beam hardening correction. Detector lag correction is based on temporal deconvolution of the measured lag response function. The effects of detector veiling glare are reduced by deconvolution of the glare response function representing the long range tails of the detector point-spread function. The performance of the correction framework is quantified in experiments using a realistic head phantom on a testbench for FPD CBCT.Uncorrected reconstructions were non-diagnostic for soft-tissue imaging tasks in the brain. After processing with the artifact correction framework, image uniformity was substantially improved, and artifacts were reduced to a level that enabled visualization of ~3 mm simulated bleeds throughout the brain. Non-uniformity (cupping) was reduced by a factor of 5, and contrast of simulated bleeds was improved from ~7 to 49.7 HU, in good agreement with the nominal blood contrast of 50 HU. Although noise was amplified by the corrections, the contrast-to-noise ratio (CNR) of simulated bleeds was improved by nearly a factor of 3.5 (CNR = 0.54 without corrections and 1.91 after correction). The resulting image quality motivates further development and translation of the FPD-CBCT system for imaging of acute TBI.},
keywords = {Artifact Correction, Beam Hardening, CBCT, Head/Neck, Scatter Estimation},
pubstate = {published},
tppubtype = {article}
}
Dang, Hao; Stayman, J. Webster; Sisniega, Alejandro; Xu, Jennifer; Zbijewski, Wojciech; Yorkston, John; Aygun, Nafi; Koliatsos, Vassilis; Siewerdsen, Jeffrey H.
Cone-Beam CT of Traumatic Brain Injury Using Statistical Reconstruction with a Post-Artifact-Correction Noise Model. Honorable Mention Conference
vol. 9412, 2015, ISSN: 0277-786X, (Wagner Award Finalist and 3rd Place Best Student Paper ).
Abstract | Links | BibTeX | Tags: -Awards-, Artifact Correction, Beam Hardening, Head/Neck, High-Fidelity Modeling, MBIR, Scatter Estimation
@conference{Dang2015a,
title = {Cone-Beam CT of Traumatic Brain Injury Using Statistical Reconstruction with a Post-Artifact-Correction Noise Model.},
author = {Hao Dang and J. Webster Stayman and Alejandro Sisniega and Jennifer Xu and Wojciech Zbijewski and John Yorkston and Nafi Aygun and Vassilis Koliatsos and Jeffrey H. Siewerdsen },
editor = {Christoph Hoeschen and Despina Kontos and Thomas G. Flohr },
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4539953},
doi = {10.1117/12.2082075},
issn = {0277-786X},
year = {2015},
date = {2015-02-01},
urldate = {2015-02-01},
journal = {Proceedings of SPIE--the International Society for Optical Engineering},
volume = {9412},
pages = {941207},
abstract = {Traumatic brain injury (TBI) is a major cause of death and disability. The current front-line imaging modality for TBI detection is CT, which reliably detects intracranial hemorrhage (fresh blood contrast 30-50 HU, size down to 1 mm) in non-contrast-enhanced exams. Compared to CT, flat-panel detector (FPD) cone-beam CT (CBCT) systems offer lower cost, greater portability, and smaller footprint suitable for point-of-care deployment. We are developing FPD-CBCT to facilitate TBI detection at the point-of-care such as in emergent, ambulance, sports, and military applications. However, current FPD-CBCT systems generally face challenges in low-contrast, soft-tissue imaging. Model-based reconstruction can improve image quality in soft-tissue imaging compared to conventional filtered backprojection (FBP) by leveraging high-fidelity forward model and sophisticated regularization. In FPD-CBCT TBI imaging, measurement noise characteristics undergo substantial change following artifact correction, resulting in non-negligible noise amplification. In this work, we extend the penalized weighted least-squares (PWLS) image reconstruction to include the two dominant artifact corrections (scatter and beam hardening) in FPD-CBCT TBI imaging by correctly modeling the variance change following each correction. Experiments were performed on a CBCT test-bench using an anthropomorphic phantom emulating intra-parenchymal hemorrhage in acute TBI, and the proposed method demonstrated an improvement in blood-brain contrast-to-noise ratio (CNR = 14.2) compared to FBP (CNR = 9.6) and PWLS using conventional weights (CNR = 11.6) at fixed spatial resolution (1 mm edge-spread width at the target contrast). The results support the hypothesis that FPD-CBCT can fulfill the image quality requirements for reliable TBI detection, using high-fidelity artifact correction and statistical reconstruction with accurate post-artifact-correction noise models.},
note = {Wagner Award Finalist and 3rd Place Best Student Paper },
keywords = {-Awards-, Artifact Correction, Beam Hardening, Head/Neck, High-Fidelity Modeling, MBIR, Scatter Estimation},
pubstate = {published},
tppubtype = {conference}
}
2014
Stayman, J. Webster; Tilley, Steven; Siewerdsen, Jeffrey H.
Integration of Component Knowledge in Penalized-Likelihood Reconstruction with Morphological and Spectral Uncertainties Proceedings Article
In: Conference proceedings/International Conference on Image Formation in X-Ray Computed Tomography. International Conference on Image Formation in X-Ray Computed Tomography, pp. 111, NIH Public Access 2014.
Links | BibTeX | Tags: Artifact Correction, Known Components, MBIR, Metal Artifacts
@inproceedings{stayman2014integration,
title = {Integration of Component Knowledge in Penalized-Likelihood Reconstruction with Morphological and Spectral Uncertainties},
author = {J. Webster Stayman and Steven Tilley and Jeffrey H. Siewerdsen },
url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211110/},
year = {2014},
date = {2014-01-01},
booktitle = {Conference proceedings/International Conference on Image Formation in X-Ray Computed Tomography. International Conference on Image Formation in X-Ray Computed Tomography},
volume = {2014},
pages = {111},
organization = {NIH Public Access},
keywords = {Artifact Correction, Known Components, MBIR, Metal Artifacts},
pubstate = {published},
tppubtype = {inproceedings}
}
Zbijewski, Wojciech; Sisniega, Alejandro; Stayman, J. Webster; Yorkston, John; Aygun, Nafi; Koliatsos, Vassilis; Siewerdsen, Jeffrey H.
A Sparse Monte Carlo Method for High-Speed, High-Accuracy Scatter Correction for Soft-Tissue Imaging in Cone-Beam CT Proceedings Article
In: Proceedings of the International Conference on Image Formation in X-Ray Computed Tomography, pp. 401–404, 2014.
BibTeX | Tags: Artifact Correction, CBCT, Scatter Estimation
@inproceedings{zbijewski2014sparse,
title = {A Sparse Monte Carlo Method for High-Speed, High-Accuracy Scatter Correction for Soft-Tissue Imaging in Cone-Beam CT},
author = {Wojciech Zbijewski and Alejandro Sisniega and J. Webster Stayman and John Yorkston and Nafi Aygun and Vassilis Koliatsos and Jeffrey H. Siewerdsen },
year = {2014},
date = {2014-01-01},
booktitle = {Proceedings of the International Conference on Image Formation in X-Ray Computed Tomography},
volume = {3},
pages = {401--404},
keywords = {Artifact Correction, CBCT, Scatter Estimation},
pubstate = {published},
tppubtype = {inproceedings}
}
2013
Stayman, J. Webster; Dang, Hao; Otake, Yoshito; Zbijewski, Wojciech; Noble, Jack; Dawant, Benoit; Labadie, Robert; Carey, John P.; Siewerdsen, Jeffrey H.
Overcoming nonlinear partial volume effects in known-component reconstruction of Cochlear implants Proceedings Article
In: Nishikawa, Robert M.; Whiting, Bruce R. (Ed.): SPIE Medical Imaging, pp. 86681L, International Society for Optics and Photonics 2013.
Links | BibTeX | Tags: Artifact Correction, Head/Neck, High-Resolution CT, Known Components, MBIR, Metal Artifacts
@inproceedings{stayman2013overcoming,
title = {Overcoming nonlinear partial volume effects in known-component reconstruction of Cochlear implants},
author = {J. Webster Stayman and Hao Dang and Yoshito Otake and Wojciech Zbijewski and Jack Noble and Benoit Dawant and Robert Labadie and John P. Carey and Jeffrey H. Siewerdsen},
editor = {Robert M. Nishikawa and Bruce R. Whiting },
url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060628/},
doi = {10.1117/12.2007945},
year = {2013},
date = {2013-03-01},
booktitle = {SPIE Medical Imaging},
pages = {86681L},
organization = {International Society for Optics and Photonics},
keywords = {Artifact Correction, Head/Neck, High-Resolution CT, Known Components, MBIR, Metal Artifacts},
pubstate = {published},
tppubtype = {inproceedings}
}
Otake, Yoshito; Stayman, J. Webster; Zbijewski, Wojciech; Murphy, Ryan J.; Kutzer, Michael D.; Taylor, Russell H.; Siewerdsen, Jeffrey H.; Armand, Mehran
Model-based cone-beam CT reconstruction for image-guided minimally invasive treatment of hip osteolysis Proceedings Article
In: III, David R. Holmes; Yaniv, Ziv R. (Ed.): SPIE Medical Imaging, pp. 86710Y, International Society for Optics and Photonics 2013.
Links | BibTeX | Tags: Artifact Correction, Image Guided Surgery, Known Components, MBIR, Metal Artifacts
@inproceedings{otake2013model,
title = {Model-based cone-beam CT reconstruction for image-guided minimally invasive treatment of hip osteolysis},
author = {Yoshito Otake and J. Webster Stayman and Wojciech Zbijewski and Ryan J. Murphy and Michael D. Kutzer and Russell H. Taylor and Jeffrey H. Siewerdsen and Mehran Armand},
editor = {David R. Holmes III and Ziv R. Yaniv },
url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2008094},
doi = {10.1117/12.2008094},
year = {2013},
date = {2013-03-01},
booktitle = {SPIE Medical Imaging},
pages = {86710Y},
organization = {International Society for Optics and Photonics},
keywords = {Artifact Correction, Image Guided Surgery, Known Components, MBIR, Metal Artifacts},
pubstate = {published},
tppubtype = {inproceedings}
}
2012
Stayman, J. Webster; Otake, Yoshito; Prince, Jerry L.; Khanna, A. Jay; Siewerdsen, Jeffrey H.
Model-based tomographic reconstruction of objects containing known components. Journal Article
In: IEEE transactions on medical imaging, vol. 31, no. 10, pp. 1837–48, 2012, ISSN: 1558-254X.
Abstract | Links | BibTeX | Tags: Artifact Correction, Image Registration, Known Components, MBIR, Metal Artifacts, Spine
@article{Stayman2012a,
title = {Model-based tomographic reconstruction of objects containing known components.},
author = {J. Webster Stayman and Yoshito Otake and Jerry L. Prince and A. Jay Khanna and Jeffrey H. Siewerdsen},
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4503263},
doi = {10.1109/TMI.2012.2199763},
issn = {1558-254X},
year = {2012},
date = {2012-10-01},
journal = {IEEE transactions on medical imaging},
volume = {31},
number = {10},
pages = {1837--48},
abstract = {The likelihood of finding manufactured components (surgical tools, implants, etc.) within a tomographic field-of-view has been steadily increasing. One reason is the aging population and proliferation of prosthetic devices, such that more people undergoing diagnostic imaging have existing implants, particularly hip and knee implants. Another reason is that use of intraoperative imaging (e.g., cone-beam CT) for surgical guidance is increasing, wherein surgical tools and devices such as screws and plates are placed within or near to the target anatomy. When these components contain metal, the reconstructed volumes are likely to contain severe artifacts that adversely affect the image quality in tissues both near and far from the component. Because physical models of such components exist, there is a unique opportunity to integrate this knowledge into the reconstruction algorithm to reduce these artifacts. We present a model-based penalized-likelihood estimation approach that explicitly incorporates known information about component geometry and composition. The approach uses an alternating maximization method that jointly estimates the anatomy and the position and pose of each of the known components. We demonstrate that the proposed method can produce nearly artifact-free images even near the boundary of a metal implant in simulated vertebral pedicle screw reconstructions and even under conditions of substantial photon starvation. The simultaneous estimation of device pose also provides quantitative information on device placement that could be valuable to quality assurance and verification of treatment delivery.},
keywords = {Artifact Correction, Image Registration, Known Components, MBIR, Metal Artifacts, Spine},
pubstate = {published},
tppubtype = {article}
}
Stayman, J. Webster; Otake, Yoshito; Schafer, Sebastian; Khanna, A. Jay; Prince, Jerry L.; Siewerdsen, Jeffrey H.
Model-based reconstruction of objects with inexactly known components Proceedings Article
In: Pelc, Norbert J.; Nishikawa, Robert M.; Whiting, Bruce R. (Ed.): SPIE Medical Imaging, pp. 83131S, 2012, ISSN: 0277-786X.
Abstract | Links | BibTeX | Tags: Artifact Correction, Image Registration, Known Components, MBIR, Metal Artifacts
@inproceedings{Stayman2012,
title = {Model-based reconstruction of objects with inexactly known components},
author = {J. Webster Stayman and Yoshito Otake and Sebastian Schafer and A. Jay Khanna and Jerry L. Prince and Jeffrey H. Siewerdsen },
editor = {Norbert J. Pelc and Robert M. Nishikawa and Bruce R. Whiting },
url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC4507268},
doi = {10.1117/12.911202},
issn = {0277-786X},
year = {2012},
date = {2012-02-01},
booktitle = {SPIE Medical Imaging},
volume = {8313},
number = {10},
pages = {83131S},
abstract = {Because tomographic reconstructions are ill-conditioned, algorithms that incorporate additional knowledge about the imaging volume generally have improved image quality. This is particularly true when measurements are noisy or have missing data. This paper presents a general reconstruction framework for including attenuation contributions from objects known to be in the field-of-view. Components such as surgical devices and tools may be modeled explicitly as part of the attenuating volume but are inexactly known with respect to their locations poses, and possible deformations. The proposed reconstruction framework, referred to as Known-Component Reconstruction (KCR), is based on this novel parameterization of the object, a likelihood-based objective function, and alternating optimizations between registration and image parameters to jointly estimate the both the underlying attenuation and unknown registrations. A deformable KCR (dKCR) approach is introduced that adopts a control point-based warping operator to accommodate shape mismatches between the component model and the physical component, thereby allowing for a more general class of inexactly known components. The KCR and dKCR approaches are applied to low-dose cone-beam CT data with spine fixation hardware present in the imaging volume. Such data is particularly challenging due to photon starvation effects in projection data behind the metallic components. The proposed algorithms are compared with traditional filtered-backprojection and penalized-likelihood reconstructions and found to provide substantially improved image quality. Whereas traditional approaches exhibit significant artifacts that complicate detection of breaches or fractures near metal, the KCR framework tends to provide good visualization of anatomy right up to the boundary of surgical devices.},
keywords = {Artifact Correction, Image Registration, Known Components, MBIR, Metal Artifacts},
pubstate = {published},
tppubtype = {inproceedings}
}
Zbijewski, Wojciech; Stayman, J. Webster; Muhit, Abdullah Al; Yorkston, John; Carrino, John A.; Siewerdsen, Jeffrey H.
CT Reconstruction Using Spectral and Morphological Prior Knowledge: Application to Imaging the Prosthetic Knee Proceedings Article
In: Second Int. Conf. Image Form. X-ray Computed Tomography, pp. 434–438, 2012.
Links | BibTeX | Tags: Artifact Correction, Beam Hardening, Extremities, Known Components, MBIR, Metal Artifacts, Spectral X-ray/CT
@inproceedings{Zbijewski2012,
title = {CT Reconstruction Using Spectral and Morphological Prior Knowledge: Application to Imaging the Prosthetic Knee},
author = {Wojciech Zbijewski and J. Webster Stayman and Abdullah Al Muhit and John Yorkston and John A. Carrino and Jeffrey H. Siewerdsen },
url = {http://istar.jhu.edu/pdf/Zbijewski_KCR_CTMeeting2012.pdf},
year = {2012},
date = {2012-01-01},
booktitle = {Second Int. Conf. Image Form. X-ray Computed Tomography},
pages = {434--438},
keywords = {Artifact Correction, Beam Hardening, Extremities, Known Components, MBIR, Metal Artifacts, Spectral X-ray/CT},
pubstate = {published},
tppubtype = {inproceedings}
}
2008
Jacobson, Matthew W.; Stayman, J. Webster
Compensating for head motion in slowly-rotating cone beam CT systems with optimization transfer based motion estimation Proceedings Article
In: 2008 IEEE Nuclear Science Symposium Conference Record, pp. 5240–5245, IEEE, 2008, ISSN: 1082-3654.
Abstract | Links | BibTeX | Tags: Artifact Correction, CBCT, Motion Compensation
@inproceedings{Jacobson2008,
title = {Compensating for head motion in slowly-rotating cone beam CT systems with optimization transfer based motion estimation},
author = {Matthew W. Jacobson and J. Webster Stayman },
url = {http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=4774416},
doi = {10.1109/NSSMIC.2008.4774416},
issn = {1082-3654},
year = {2008},
date = {2008-10-01},
booktitle = {2008 IEEE Nuclear Science Symposium Conference Record},
pages = {5240--5245},
publisher = {IEEE},
abstract = {We present an algorithm that estimates the changing pose of a rigidly moving subject, based on tomographic projections of fiducial markers. The pose estimates can then be used as input data to motion-compensated image reconstruction methods. The proposed algorithm is in the family of so-called optimization transfer algorithms, which have been applied more frequently to tomographic image reconstruction (e.g., the ML-EM algorithm for PET). The algorithm is particularly relevant to the class of slowly-rotating, point-of-care cone beam CT systems, which have recently become prominent in otolaryngological and dental clinics for head and neck scanning. These systems are more compact and inexpensive than traditional CT systems, but because of their slower gantry rotation, are more susceptible to patient head motion over the course of the scan. A virtue of our algorithm is that it does not require a priori knowledge of the marker geometry. The relative positions of the markers are co-estimated together with their 6 degree of freedom position/orientation in each projection view. This means that the marker configuration can be deformably adjusted to fit different patients, giving considerably more flexibility in the design of the marker-to-head attachment gear than with conventional fiducial-based approaches. Our algorithm is also both fast and accurate. In a highly sub-optimal MATLAB implementation, we typically achieve motion estimates yielding sub-millimeter positioning error in 15–30 seconds. We also present motion-compensated reconstructions from real CT acquisitions as evidence of motion-estimation performance.},
keywords = {Artifact Correction, CBCT, Motion Compensation},
pubstate = {published},
tppubtype = {inproceedings}
}